Searches for Topologically and Three Dimensionally Similar Structures in Proteins

نویسندگان

  • Kenji Satou
  • Emiko Furuichi
چکیده

We developed a deductive database system PACADE for analyzing three dimensional and secondary structures of protein. PACADE is equipped with a function to search for similar structures in proteins. Unlike other approaches based on calculation of the inter-atomic root mean square distance, this function is based on logic programming and source level rule rewriting techniques. We describe herein the result of searches for topologically similar structures and three dimensionally similar ones. A user of PACADE can select these two levels of similarities by adding/deleting pre xes. 1:4F#8-Fs: 6e=#Bg3X9)3XIt>pJs9)3X2J, ") 812 J!2,;TEl6hH":j 6-10-1 28E;T7CH~;R: J!2,=w;RC;4|Bg3X, ") 818-01 B@:KI\;T8^>r 4-16-1 35W86E/: 6e=#Bg3XBg3X1!G@3X8&5f2J0dEA;R;q8;9)3X@l96, ") 812 J!2,;TEl6hH":j 6-10-1 49bLZMx5W: El5~Bg3X0e2J3X8&5f=j%R%H%2%N%‘2r@O%;%s%?!<, ") 108 El5~ET9A6hGr6bBf 4-6-1

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Application of a deductive database system to search for topological and similar three-dimensional structures in protein

A deductive database system PACADE (Protein Atomic Coordinate Analyzer with Deductive Engine) has been developed for protein structure analysis. With this system, super-secondary structures described in logical and declarative rules can be retrieved effectively. For protein structure analysis, comparison of local structures in different proteins is a necessary mean. A function to search for sim...

متن کامل

A COMPRATIVE STUDY OF THREE METAHEURISTICS FOR OPTIMUM DESIGN OF TRUSSES

In the present study, the computational performance of the particle swarm optimization (PSO) harmony search (HS) and firefly algorithm (FA), as popular metaheuristics, is investigated for size and shape optimization of truss structures. The PSO was inspired by the social behavior of organisms such as bird flocking. The HS imitates the musical performance process which takes place when a musicia...

متن کامل

KH domain: one motif, two folds.

The K homology (KH) module is a widespread RNA-binding motif that has been detected by sequence similarity searches in such proteins as heterogeneous nuclear ribonucleoprotein K (hnRNP K) and ribosomal protein S3. Analysis of spatial structures of KH domains in hnRNP K and S3 reveals that they are topologically dissimilar and thus belong to different protein folds. Thus KH motif proteins provid...

متن کامل

TOPOLOGICALLY STATIONARY LOCALLY COMPACT SEMIGROUP AND AMENABILITY

In this paper, we investigate the concept of topological stationary for locally compact semigroups. In [4], T. Mitchell proved that a semigroup S is right stationary if and only if m(S) has a left Invariant mean. In this case, the set of values ?(f) where ? runs over all left invariant means on m(S) coincides with the set of constants in the weak* closed convex hull of right translates of f. Th...

متن کامل

Molecular Docking of Curcumin With Breast Cancer Cell Line Proteins

Background: Breast cancer is known as the most widely recognized dangerous tumors; therefore, the most common reason for mortality among all instances of harmful neoplastic illness in females. This is because the lack of specific signs and symptoms at the early stage and at the aggressive nature. Currently, breast cancer treatment such as chemotherapy, surgery and radiotherapy has not been effe...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1993